| 2. Jornada | 03.08.2021 | Boyacá Chicó | - | Real Cartagena | 1:0 | ||||
| 6. Jornada | 31.08.2021 | Unión Magdalena | - | Real Cartagena | 1:0 | ||||
| 7. Jornada | 04.09.2021 | Real Cartagena | - | Boca Juniors de Cali | 2:0 | ||||
| 9. Jornada | 19.09.2021 | Leones FC | - | Real Cartagena | 2:0 | ||||
| 10. Jornada | 29.09.2021 | Real Cartagena | - | Llaneros FC | 2:1 | ||||
| 11. Jornada | 06.10.2021 | Tigres FC | - | Real Cartagena | 1:2 | ||||
| 12. Jornada | 12.10.2021 | Real Cartagena | - | Barranquilla FC | 3:1 | ||||
| 13. Jornada | 20.10.2021 | Bogotá FC | - | Real Cartagena | 0:0 | ||||
| 14. Jornada | 26.10.2021 | Real Cartagena | - | Atlético FC | 1:1 |  |
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| 15. Jornada | 30.10.2021 | Orsomarso SC | - | Real Cartagena | 1:1 | |
Colombia