| 11. Jornada | 04.10.2021 | Academica Clinceni | - | FC Botoşani | 1:1 |  |
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| 12. Jornada | 18.10.2021 | FC Botoşani | - | Chindia Târgoviște | 0:0 | |
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| 13. Jornada | 23.10.2021 | CS Mioveni | - | FC Botoşani | 1:1 | ||||
| 14. Jornada | 29.10.2021 | FC Botoşani | - | Farul Constanța | 0:2 | ||||
| 21. Jornada | 18.12.2021 | Rapid Bucureşti | - | FC Botoşani | 1:1 | ||||
| 22. Jornada | 24.01.2022 | FC Botoşani | - | Sepsi OSK | 1:0 | ||||
| 23. Jornada | 31.01.2022 | CFR Cluj | - | FC Botoşani | 1:1 | ||||
| 26. Jornada | 14.02.2022 | FC Botoşani | - | Academica Clinceni | 2:0 | ||||
| 27. Jornada | 20.02.2022 | Chindia Târgoviște | - | FC Botoşani | 1:1 | ||||
| 28. Jornada | 27.02.2022 | FC Botoşani | - | CS Mioveni | 0:0 | |
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| 30. Jornada | 07.03.2022 | FC Botoşani | - | Argeș Pitești | 1:2 |
Portugal
R.D. Congo