| 1. Jornada | 23.01.2022 | Tigres FC | - | Real Cartagena | 1:2 |  |
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| 2. Jornada | 30.01.2022 | Real Santander | - | Tigres FC | 0:0 | ||||
| 3. Jornada | 05.02.2022 | Tigres FC | - | Atlético FC | 1:1 | ||||
| 5. Jornada | 18.02.2022 | Tigres FC | - | Bogotá FC | 3:0 | ||||
| 6. Jornada | 26.02.2022 | Orsomarso SC | - | Tigres FC | 0:2 | |
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| 7. Jornada | 06.03.2022 | Tigres FC | - | Llaneros FC | 0:1 | |
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| 8. Jornada | 11.03.2022 | Deportes Quindío | - | Tigres FC | 0:0 | ||||
| 9. Jornada | 22.03.2022 | Tigres FC | - | Boyacá Chicó | 1:0 | ||||
| 10. Jornada | 26.03.2022 | Boca Juniors de Cali | - | Tigres FC | 2:0 | |
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| 11. Jornada | 03.04.2022 | Tigres FC | - | Valledupar FC | 3:2 | |
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| 14. Jornada | 25.04.2022 | Tigres FC | - | Barranquilla FC | 2:0 | ||||
| 15. Jornada | 04.05.2022 | Atlético Huila | - | Tigres FC | 0:0 |
Colombia