| 2. Jornada | 02.08.2021 | Pirin Blagoevgrad | - | PFC Beroe | 2:3 | ||||
| 4. Jornada | 13.08.2021 | Pirin Blagoevgrad | - | CSKA 1948 Sofia | 4:1 | ||||
| 5. Jornada | 22.08.2021 | CSKA Sofia | - | Pirin Blagoevgrad | 1:0 | ||||
| 9. Jornada | 27.09.2021 | Pirin Blagoevgrad | - | Cherno More Varna | 2:2 |  |
|||
| 11. Jornada | 15.10.2021 | Pirin Blagoevgrad | - | Botev Vratsa | 3:1 | ||||
| 13. Jornada | 31.10.2021 | Pirin Blagoevgrad | - | Tsarsko Selo Sofia | 2:1 | ||||
| 14. Jornada | 06.11.2021 | Pirin Blagoevgrad | - | Botev Plovdiv | 0:1 | ||||
| 15. Jornada | 19.11.2021 | PFC Beroe | - | Pirin Blagoevgrad | 1:1 | ||||
| 16. Jornada | 27.11.2021 | Pirin Blagoevgrad | - | Lokomotiv Plovdiv | 2:3 | ||||
| 17. Jornada | 02.12.2021 | CSKA 1948 Sofia | - | Pirin Blagoevgrad | 1:0 | ||||
| 18. Jornada | 05.12.2021 | Pirin Blagoevgrad | - | CSKA Sofia | 1:1 | ||||
| 20. Jornada | 21.02.2022 | Pirin Blagoevgrad | - | Lokomotiv Sofia | 2:1 | ||||
| 21. Jornada | 28.02.2022 | Pirin Blagoevgrad | - | Arda Kardzhali | 1:0 | ||||
| 22. Jornada | 05.03.2022 | Cherno More Varna | - | Pirin Blagoevgrad | 1:1 | ||||
| 23. Jornada | 14.03.2022 | Pirin Blagoevgrad | - | Slavia Sofia | 0:0 | ||||
| 24. Jornada | 20.03.2022 | Botev Vratsa | - | Pirin Blagoevgrad | 0:3 |
Bulgaria