| 1. Jornada | 16.01.2022 | Alianza | - | Isidro Metapán | 0:2 | ||||
| 2. Jornada | 23.01.2022 | Isidro Metapán | - | AD Chalatenango | 2:1 | ||||
| 3. Jornada | 27.01.2022 | Luis Ángel Firpo | - | Isidro Metapán | 0:0 | ||||
| 4. Jornada | 30.01.2022 | Isidro Metapán | - | Platense Zacatecoluca | 0:0 | ||||
| 5. Jornada | 06.02.2022 | Once Municipal | - | Isidro Metapán | 0:0 |  |
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| 6. Jornada | 10.02.2022 | Isidro Metapán | - | CD Águila | 2:2 | |
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| 12. Jornada | 13.03.2022 | Isidro Metapán | - | Alianza | 0:0 | ||||
| 13. Jornada | 20.03.2022 | AD Chalatenango | - | Isidro Metapán | 1:1 | ||||
| 14. Jornada | 24.03.2022 | Isidro Metapán | - | Luis Ángel Firpo | 1:1 | ||||
| 15. Jornada | 03.04.2022 | Platense Zacatecoluca | - | Isidro Metapán | 2:1 | |
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| 16. Jornada | 10.04.2022 | Isidro Metapán | - | Once Municipal | 2:2 | ||||
| 17. Jornada | 14.04.2022 | CD Águila | - | Isidro Metapán | 1:3 | |
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| 18. Jornada | 17.04.2022 | Isidro Metapán | - | Jocoro FC | 3:0 | ||||
| 19. Jornada | 24.04.2022 | FAS | - | Isidro Metapán | 4:1 | ||||
| 21. Jornada | 01.05.2022 | Municipal Limeño | - | Isidro Metapán | 1:0 | ||||
| 22. Jornada | 07.05.2022 | Isidro Metapán | - | Atlético Marte | 1:1 |
El Salvador