| 2. Jornada | 16.01.2022 | LD Alajuelense | - | Guadalupe | 1:0 | ||||
| 3. Jornada | 21.01.2022 | Sporting FC | - | Guadalupe | 2:2 |  |
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| 4. Jornada | 04.02.2022 | Guadalupe | - | AD San Carlos | 3:1 | ||||
| 5. Jornada | 10.02.2022 | Guadalupe | - | Municipal Grecia | 3:1 | ||||
| 6. Jornada | 12.02.2022 | Jicaral | - | Guadalupe | 2:0 | ||||
| 7. Jornada | 19.02.2022 | Guadalupe | - | Santos de Guápiles | 4:1 | |
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| 8. Jornada | 27.02.2022 | Deportivo Saprissa | - | Guadalupe | 2:1 | |
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| 9. Jornada | 03.03.2022 | Municipal Pérez Zeledón | - | Guadalupe | 0:1 | ||||
| 10. Jornada | 06.03.2022 | Guadalupe | - | CS Herediano | 1:1 | ||||
| 11. Jornada | 01.04.2022 | AD Guanacasteca | - | Guadalupe | 1:2 | ||||
| 12. Jornada | 08.04.2022 | CS Cartaginés | - | Guadalupe | 4:1 | ||||
| 13. Jornada | 11.04.2022 | Guadalupe | - | LD Alajuelense | 0:2 | |
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| 14. Jornada | 17.04.2022 | Guadalupe | - | Sporting FC | 4:2 | ||||
| 16. Jornada | 24.04.2022 | Municipal Grecia | - | Guadalupe | 3:2 | ||||
| 17. Jornada | 28.04.2022 | Guadalupe | - | Jicaral | 1:0 | ||||
| 19. Jornada | 05.05.2022 | Guadalupe | - | Deportivo Saprissa | 1:2 | ||||
| 20. Jornada | 08.05.2022 | Guadalupe | - | Municipal Pérez Zeledón | 2:2 | ||||
| 21. Jornada | 13.05.2022 | CS Herediano | - | Guadalupe | 0:0 |
Costa Rica