| 1. Jornada | 18.01.2021 | Deportes Tolima | - | Once Caldas | 1:1 | ||||
| 6. Jornada | 15.02.2021 | Deportivo Pasto | - | Deportes Tolima | 0:1 | ||||
| 8. Jornada | 20.02.2021 | Deportes Tolima | - | Patriotas FC | 3:1 |  |
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| 9. Jornada | 26.02.2021 | Alianza Petrolera | - | Deportes Tolima | 0:5 | ||||
| 10. Jornada | 28.02.2021 | Deportes Tolima | - | Águilas Doradas | 1:0 | ||||
| 2. Jornada | 05.03.2021 | Santa Fe | - | Deportes Tolima | 3:2 | ||||
| 11. Jornada | 08.03.2021 | Boyacá Chicó | - | Deportes Tolima | 2:1 | ||||
| 12. Jornada | 13.03.2021 | Deportes Tolima | - | Jaguares de Córdoba | 3:2 | ||||
| 14. Jornada | 24.03.2021 | Deportes Tolima | - | Atlético Junior | 0:1 |
Colombia