| 1. Jornada | 19.07.2021 | Libertad | - | Guaireña FC | 0:0 | ||||
| 2. Jornada | 25.07.2021 | Guaireña FC | - | River Plate | 1:2 | ||||
| 3. Jornada | 02.08.2021 | Club Olimpia | - | Guaireña FC | 0:2 |  |
|||
| 4. Jornada | 08.08.2021 | Cerro Porteño | - | Guaireña FC | 2:0 | ||||
| 5. Jornada | 13.08.2021 | Guaireña FC | - | Sol de América | 1:1 | ||||
| 6. Jornada | 21.08.2021 | Club Nacional | - | Guaireña FC | 0:2 | |
|||
| 7. Jornada | 31.08.2021 | Guaireña FC | - | 12 de Octubre de Itauguá | 0:1 | ||||
| 8. Jornada | 12.09.2021 | Guaraní | - | Guaireña FC | 3:0 | ||||
| 9. Jornada | 20.09.2021 | Guaireña FC | - | Sportivo Luqueño | 1:2 |  |
|||
| 10. Jornada | 27.09.2021 | Guaireña FC | - | Libertad | 2:1 | ||||
| 11. Jornada | 03.10.2021 | River Plate | - | Guaireña FC | 1:1 | ||||
| 12. Jornada | 18.10.2021 | Guaireña FC | - | Club Olimpia | 0:2 | ||||
| 13. Jornada | 25.10.2021 | Guaireña FC | - | Cerro Porteño | 0:2 | ||||
| 14. Jornada | 01.11.2021 | Sol de América | - | Guaireña FC | 3:0 |
Paraguay