| 5. Jornada | 09.02.2022 | AD Guanacasteca | - | Municipal Pérez Zeledón | 0:0 | ||||
| 7. Jornada | 20.02.2022 | Municipal Pérez Zeledón | - | Deportivo Saprissa | 0:0 | ||||
| 11. Jornada | 01.04.2022 | CS Herediano | - | Municipal Pérez Zeledón | 3:2 | ||||
| 12. Jornada | 05.04.2022 | Municipal Grecia | - | Municipal Pérez Zeledón | 2:0 | ||||
| 13. Jornada | 11.04.2022 | Municipal Pérez Zeledón | - | CS Cartaginés | 3:0 |  |
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| 15. Jornada | 20.04.2022 | LD Alajuelense | - | Municipal Pérez Zeledón | 3:1 |  |
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| 16. Jornada | 24.04.2022 | Municipal Pérez Zeledón | - | AD Guanacasteca | 2:2 | ||||
| 17. Jornada | 27.04.2022 | Municipal Pérez Zeledón | - | Santos de Guápiles | 1:1 | ||||
| 18. Jornada | 02.05.2022 | Deportivo Saprissa | - | Municipal Pérez Zeledón | 2:1 | |
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| 19. Jornada | 05.05.2022 | Municipal Pérez Zeledón | - | Sporting FC | 0:1 | ||||
| 20. Jornada | 08.05.2022 | Guadalupe | - | Municipal Pérez Zeledón | 2:2 | |
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| 21. Jornada | 11.05.2022 | Jicaral | - | Municipal Pérez Zeledón | 2:1 | ||||
| 22. Jornada | 15.05.2022 | Municipal Pérez Zeledón | - | CS Herediano | 2:3 | |
Costa Rica