| 14. Jornada | 30.10.2021 | Boreham Wood | - | Southend United | 1:0 | ||||
| 13. Jornada | 02.11.2021 | Southend United | - | Dover Athletic | 4:1 | ||||
| 15. Jornada | 13.11.2021 | Southend United | - | Woking FC | 0:2 | ||||
| 16. Jornada | 19.11.2021 | Grimsby Town | - | Southend United | 1:0 | ||||
| 18. Jornada | 27.11.2021 | Altrincham FC | - | Southend United | 1:2 |  |
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| 17. Jornada | 07.12.2021 | Southend United | - | Maidenhead United | 1:1 | |
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| 24. Jornada | 08.01.2022 | Weymouth FC | - | Southend United | 0:1 | ||||
| 19. Jornada | 11.01.2022 | Southend United | - | Yeovil Town | 2:1 | |
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| 25. Jornada | 21.01.2022 | Southend United | - | King's Lynn | 2:1 | ||||
| 26. Jornada | 25.01.2022 | Aldershot Town | - | Southend United | 1:1 | |
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| 27. Jornada | 29.01.2022 | Dover Athletic | - | Southend United | 0:1 | ||||
| 22. Jornada | 01.02.2022 | Southend United | - | Barnet FC | 2:1 | ||||
| 23. Jornada | 08.02.2022 | Southend United | - | Bromley FC | 2:0 | ||||
| 29. Jornada | 12.02.2022 | Woking FC | - | Southend United | 2:3 | ||||
| 31. Jornada | 22.02.2022 | Eastleigh FC | - | Southend United | 1:1 | ||||
| 33. Jornada | 05.03.2022 | Chesterfield FC | - | Southend United | 2:2 | ||||
| 30. Jornada | 08.03.2022 | Southend United | - | Grimsby Town | 1:0 |
Polonia