| 2. Jornada | 01.08.2021 | Guadalupe | - | AD San Carlos | 1:1 | ||||
| 3. Jornada | 07.08.2021 | AD San Carlos | - | Municipal Pérez Zeledón | 1:1 | ||||
| 13. Jornada | 26.09.2021 | AD San Carlos | - | Guadalupe | 4:2 | ||||
| 14. Jornada | 03.10.2021 | Municipal Pérez Zeledón | - | AD San Carlos | 1:1 | ||||
| 15. Jornada | 13.10.2021 | AD San Carlos | - | CS Cartaginés | 0:1 | ||||
| 16. Jornada | 17.10.2021 | Jicaral | - | AD San Carlos | 0:4 | ||||
| 17. Jornada | 23.10.2021 | AD San Carlos | - | CS Herediano | 0:0 | ||||
| 18. Jornada | 28.10.2021 | AD San Carlos | - | Sporting FC | 3:1 | ||||
| 19. Jornada | 01.11.2021 | AD Guanacasteca | - | AD San Carlos | 0:1 | ||||
| 22. Jornada | 28.11.2021 | AD San Carlos | - | Municipal Grecia | 1:3 |
Costa Rica
Nicaragua