| 1. Jornada | 16.01.2021 | Real Cartagena | - | Cortuluá | 2:1 | ||||
| 2. Jornada | 23.01.2021 | Atlético FC | - | Real Cartagena | 3:0 |  |
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| 3. Jornada | 01.02.2021 | Real Cartagena | - | Barranquilla FC | 1:0 | ||||
| 4. Jornada | 09.02.2021 | Valledupar FC | - | Real Cartagena | 2:0 | ||||
| 5. Jornada | 11.02.2021 | Real Cartagena | - | Llaneros FC | 3:1 | ||||
| 6. Jornada | 16.02.2021 | Unión Magdalena | - | Real Cartagena | 2:1 | |
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| 7. Jornada | 20.02.2021 | Real Cartagena | - | Deportes Quindío | 2:3 | |
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| 8. Jornada | 27.02.2021 | Orsomarso SC | - | Real Cartagena | 3:3 | ||||
| 10. Jornada | 06.03.2021 | Tigres FC | - | Real Cartagena | 0:0 | ||||
| 11. Jornada | 14.03.2021 | Real Santander | - | Real Cartagena | 0:3 | |
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| 12. Jornada | 22.03.2021 | Real Cartagena | - | Bogotá FC | 1:1 | ||||
| 13. Jornada | 28.03.2021 | Fortaleza FC | - | Real Cartagena | 1:1 | |
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| 15. Jornada | 09.04.2021 | Atlético Huila | - | Real Cartagena | 4:1 |
Colombia