| 1. Jornada | 23.07.2021 | PFC Beroe | - | Lokomotiv Sofia | 1:0 |  |
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| 2. Jornada | 02.08.2021 | Pirin Blagoevgrad | - | PFC Beroe | 2:3 | ||||
| 3. Jornada | 07.08.2021 | PFC Beroe | - | Cherno More Varna | 0:2 | ||||
| 4. Jornada | 14.08.2021 | Slavia Sofia | - | PFC Beroe | 3:2 | ||||
| 5. Jornada | 23.08.2021 | PFC Beroe | - | Botev Vratsa | 1:0 | |
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| 6. Jornada | 28.08.2021 | Levski Sofia | - | PFC Beroe | 2:1 | |
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| 7. Jornada | 13.09.2021 | PFC Beroe | - | Tsarsko Selo Sofia | 1:0 | |
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| 8. Jornada | 17.09.2021 | Botev Plovdiv | - | PFC Beroe | 2:1 | ||||
| 11. Jornada | 18.10.2021 | CSKA 1948 Sofia | - | PFC Beroe | 1:0 | ||||
| 12. Jornada | 24.10.2021 | PFC Beroe | - | CSKA Sofia | 0:0 | ||||
| 13. Jornada | 31.10.2021 | PFC Ludogorets Razgrad | - | PFC Beroe | 2:0 | |
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| 15. Jornada | 19.11.2021 | PFC Beroe | - | Pirin Blagoevgrad | 1:1 | ||||
| 16. Jornada | 26.11.2021 | Cherno More Varna | - | PFC Beroe | 1:0 | |
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| 19. Jornada | 12.12.2021 | PFC Beroe | - | Levski Sofia | 1:1 |
Bulgaria