| 4. Jornada | 30.01.2022 | Atlético Marte | - | Once Municipal | 1:1 | ||||
| 5. Jornada | 06.02.2022 | Once Municipal | - | Isidro Metapán | 0:0 | ||||
| 6. Jornada | 10.02.2022 | AD Chalatenango | - | Once Municipal | 1:0 | ||||
| 7. Jornada | 13.02.2022 | Once Municipal | - | Luis Ángel Firpo | 1:0 | ||||
| 11. Jornada | 05.03.2022 | Jocoro FC | - | Once Municipal | 2:1 | ||||
| 12. Jornada | 13.03.2022 | FAS | - | Once Municipal | 0:0 | ||||
| 13. Jornada | 19.03.2022 | Once Municipal | - | Santa Tecla FC | 1:0 | ||||
| 14. Jornada | 25.03.2022 | Municipal Limeño | - | Once Municipal | 0:0 |  |
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| 15. Jornada | 03.04.2022 | Once Municipal | - | Atlético Marte | 1:0 | ||||
| 16. Jornada | 10.04.2022 | Isidro Metapán | - | Once Municipal | 2:2 | ||||
| 17. Jornada | 13.04.2022 | Once Municipal | - | AD Chalatenango | 0:1 |  |
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| 20. Jornada | 29.04.2022 | Alianza | - | Once Municipal | 1:0 | |
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| 21. Jornada | 01.05.2022 | CD Águila | - | Once Municipal | 0:1 | |
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| 22. Jornada | 07.05.2022 | Once Municipal | - | Jocoro FC | 0:1 |
Jamaica