| 4. Jornada | 08.08.2021 | Hrvatski Dragovoljac | - | NK Osijek | 1:2 | ||||
| 5. Jornada | 15.08.2021 | NK Osijek | - | HNK Rijeka | 1:0 | ||||
| 7. Jornada | 29.08.2021 | NK Osijek | - | Dinamo Zagreb | 0:2 | ||||
| 8. Jornada | 12.09.2021 | Lokomotiva Zagreb | - | NK Osijek | 1:1 | ||||
| 9. Jornada | 19.09.2021 | NK Osijek | - | HNK Gorica | 3:2 |  |
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| 10. Jornada | 25.09.2021 | HNK Šibenik | - | NK Osijek | 0:2 | |
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| 11. Jornada | 03.10.2021 | NK Osijek | - | Hajduk Split | 1:1 | ||||
| 15. Jornada | 06.11.2021 | NK Osijek | - | NK Istra 1961 | 3:0 | ||||
| 16. Jornada | 20.11.2021 | Dinamo Zagreb | - | NK Osijek | 1:1 | ||||
| 17. Jornada | 26.11.2021 | NK Osijek | - | Lokomotiva Zagreb | 3:1 | |
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| 19. Jornada | 12.12.2021 | NK Osijek | - | HNK Šibenik | 3:1 | ||||
| 33. Jornada | 01.05.2022 | NK Osijek | - | NK Istra 1961 | 2:2 | ||||
| 34. Jornada | 08.05.2022 | Dinamo Zagreb | - | NK Osijek | 3:0 | ||||
| 35. Jornada | 15.05.2022 | NK Osijek | - | Lokomotiva Zagreb | 1:0 | ||||
| 36. Jornada | 21.05.2022 | HNK Gorica | - | NK Osijek | 1:1 |  |
Croacia