| 1. Jornada | 12.09.2021 | PAOK Saloniki | - | PAS Giannina | 0:1 | ||||
| 2. Jornada | 19.09.2021 | Asteras Tripolis | - | PAOK Saloniki | 0:1 | ||||
| 3. Jornada | 22.09.2021 | Panetolikos | - | PAOK Saloniki | 1:2 | ||||
| 4. Jornada | 26.09.2021 | PAOK Saloniki | - | AEK Athen | 2:0 |  |
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| 5. Jornada | 03.10.2021 | OFI Heraklion | - | PAOK Saloniki | 1:3 |  |
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| 6. Jornada | 17.10.2021 | PAOK Saloniki | - | Volos NFC | 4:4 | ||||
| 7. Jornada | 24.10.2021 | Olympiacos | - | PAOK Saloniki | 2:1 | ||||
| 8. Jornada | 30.10.2021 | PAOK Saloniki | - | Apollon Smyrnis | 4:1 | |
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| 9. Jornada | 07.11.2021 | Panathinaikos | - | PAOK Saloniki | 1:3 | ||||
| 10. Jornada | 21.11.2021 | Atromitos | - | PAOK Saloniki | 2:0 | ||||
| 11. Jornada | 28.11.2021 | PAOK Saloniki | - | Aris Saloniki | 0:1 | ||||
| 12. Jornada | 05.12.2021 | Ionikos Nikea | - | PAOK Saloniki | 3:2 | |
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| 13. Jornada | 12.12.2021 | PAOK Saloniki | - | Lamia | 2:1 | ||||
| 15. Jornada | 19.12.2021 | PAOK Saloniki | - | Asteras Tripolis | 3:2 | ||||
| 16. Jornada | 12.01.2022 | PAOK Saloniki | - | Panetolikos | 2:0 | ||||
| 18. Jornada | 15.01.2022 | PAOK Saloniki | - | OFI Heraklion | 3:0 | |
Polonia