| 4. Jornada | 22.08.2021 | Lobos UPNFM | - | Platense | 3:0 | ||||
| 5. Jornada | 27.08.2021 | Platense | - | Marathón | 3:1 | ||||
| 6. Jornada | 29.08.2021 | Real Sociedad | - | Platense | 1:1 | ||||
| 7. Jornada | 02.09.2021 | Olimpia | - | Platense | 3:0 | ||||
| 8. Jornada | 13.09.2021 | Platense | - | Vida | 1:4 | ||||
| 9. Jornada | 16.09.2021 | Victoria | - | Platense | 2:0 | ||||
| 10. Jornada | 20.09.2021 | Platense | - | Real Sociedad | 2:3 |  |
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| 11. Jornada | 27.09.2021 | Platense | - | Lobos UPNFM | 2:3 | ||||
| 12. Jornada | 03.10.2021 | Honduras Progreso | - | Platense | 4:2 | |
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| 15. Jornada | 24.10.2021 | Marathón | - | Platense | 1:1 | ||||
| 16. Jornada | 28.10.2021 | Platense | - | Victoria | 1:2 |
Honduras