| 1. Jornada | 17.09.2000 | Panachaiki GE | - | Skoda Xanthi | 1:1 | ||||
| 2. Jornada | 24.09.2000 | Iraklis Saloniki | - | Panachaiki GE | 2:0 | ||||
| 3. Jornada | 01.10.2000 | Panachaiki GE | - | Athinaikos | 3:1 | ||||
| 4. Jornada | 30.10.2000 | Ethnikos Asteras | - | Panachaiki GE | 3:1 | ||||
| 5. Jornada | 06.11.2000 | Panachaiki GE | - | Ionikos Nikea | 2:3 | ||||
| 6. Jornada | 12.11.2000 | AEK Athen | - | Panachaiki GE | 2:1 | ||||
| 7. Jornada | 19.11.2000 | Olympiacos | - | Panachaiki GE | 3:0 | ||||
| 8. Jornada | 26.11.2000 | Panachaiki GE | - | PS Kalamata | 3:2 | ||||
| 12. Jornada | 03.01.2001 | Panachaiki GE | - | OFI Heraklion | 2:1 | ||||
| 13. Jornada | 07.01.2001 | Paniliakos Pyrgos | - | Panachaiki GE | 2:2 | ||||
| 17. Jornada | 04.02.2001 | Panachaiki GE | - | Iraklis Saloniki | 1:2 | ||||
| 18. Jornada | 11.02.2001 | Athinaikos | - | Panachaiki GE | 3:1 | ||||
| 21. Jornada | 05.03.2001 | Panachaiki GE | - | AEK Athen | 1:0 | ||||
| 22. Jornada | 11.03.2001 | Panachaiki GE | - | Olympiacos | 1:5 |  |
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| 23. Jornada | 18.03.2001 | PS Kalamata | - | Panachaiki GE | 3:3 | ||||
| 24. Jornada | 01.04.2001 | Panachaiki GE | - | PAS Giannina | 2:1 |  |
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| 25. Jornada | 08.04.2001 | Panionios GSS | - | Panachaiki GE | 2:0 |
Liberia