| 2. Jornada | 24.08.2021 | Chippa United | - | Mamelodi Sundowns | 0:0 | ||||
| 3. Jornada | 12.09.2021 | Mamelodi Sundowns | - | Kaizer Chiefs | 2:0 | ||||
| 4. Jornada | 19.09.2021 | Mamelodi Sundowns | - | TS Galaxy | 3:0 | ||||
| 5. Jornada | 25.09.2021 | Orlando Pirates | - | Mamelodi Sundowns | 0:2 | ||||
| 12. Jornada | 27.11.2021 | Mamelodi Sundowns | - | Sekhukhune United | 2:0 | ||||
| 13. Jornada | 04.12.2021 | Stellenbosch FC | - | Mamelodi Sundowns | 1:1 | ||||
| 22. Jornada | 14.12.2021 | Mamelodi Sundowns | - | Baroka FC | 2:1 |  |
 |
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| 20. Jornada | 02.03.2022 | TS Galaxy | - | Mamelodi Sundowns | 0:3 | ||||
| 25. Jornada | 12.04.2022 | Mamelodi Sundowns | - | Golden Arrows | 6:0 |  |
Sudáfrica