| 1. Jornada | 20.01.2022 | Victoria | - | Real España | 4:1 |  |
|||
| 2. Jornada | 24.01.2022 | Platense | - | Real España | 2:1 | ||||
| 3. Jornada | 06.02.2022 | Real España | - | Motagua | 1:2 | |
|||
| 4. Jornada | 11.02.2022 | Marathón | - | Real España | 2:0 | ||||
| 5. Jornada | 14.02.2022 | Real España | - | Real Sociedad | 4:1 | ||||
| 6. Jornada | 20.02.2022 | Olimpia | - | Real España | 1:3 | |
|||
| 7. Jornada | 27.02.2022 | Real España | - | Honduras Progreso | 3:0 | ||||
| 8. Jornada | 03.03.2022 | Real España | - | Lobos UPNFM | 1:0 | ||||
| 9. Jornada | 06.03.2022 | Vida | - | Real España | 0:1 | ||||
| 10. Jornada | 13.03.2022 | Motagua | - | Real España | 0:2 | ||||
| 11. Jornada | 20.03.2022 | Real España | - | Platense | 3:2 |  |
|||
| 13. Jornada | 07.04.2022 | Real Sociedad | - | Real España | 0:3 | ||||
| 14. Jornada | 11.04.2022 | Real España | - | Olimpia | 1:0 | |
|||
| 16. Jornada | 21.04.2022 | Real España | - | Victoria | 3:1 | ||||
| 17. Jornada | 24.04.2022 | Honduras Progreso | - | Real España | 1:1 | ||||
| 12. Jornada | 28.04.2022 | Real España | - | Marathón | 3:1 | ||||
| 18. Jornada | 01.05.2022 | Real España | - | Vida | 1:4 |
Honduras