| 1. Jornada | 10.07.2022 | Atlético Huila | - | Valledupar FC | 3:2 | ||||
| 2. Jornada | 17.07.2022 | Valledupar FC | - | Boyacá Chicó | 0:0 | ||||
| 3. Jornada | 23.07.2022 | Orsomarso SC | - | Valledupar FC | 1:1 | ||||
| 4. Jornada | 01.08.2022 | Deportes Quindío | - | Valledupar FC | 4:3 | ||||
| 5. Jornada | 04.08.2022 | Valledupar FC | - | Llaneros FC | 1:1 |  |
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| 6. Jornada | 08.08.2022 | Boca Juniors de Cali | - | Valledupar FC | 2:0 | ||||
| 7. Jornada | 14.08.2022 | Valledupar FC | - | Tigres FC | 1:1 | ||||
| 8. Jornada | 23.08.2022 | Valledupar FC | - | Bogotá FC | 3:3 | |
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| 9. Jornada | 27.08.2022 | Leones FC | - | Valledupar FC | 1:0 | ||||
| 10. Jornada | 03.09.2022 | Valledupar FC | - | Real Cartagena | 1:1 | ||||
| 11. Jornada | 07.09.2022 | Real Santander | - | Valledupar FC | 1:0 | ||||
| 12. Jornada | 11.09.2022 | Valledupar FC | - | Atlético FC | 1:0 | ||||
| 13. Jornada | 18.09.2022 | Cúcuta Deportivo | - | Valledupar FC | 2:1 | |
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| 16. Jornada | 08.10.2022 | Fortaleza FC | - | Valledupar FC | 3:1 |
Colombia