| 1. Jornada | 01.08.2021 | Luis Ángel Firpo | - | Jocoro FC | 1:1 | ||||
| 3. Jornada | 04.08.2021 | FAS | - | Jocoro FC | 4:1 | ||||
| 2. Jornada | 08.08.2021 | Jocoro FC | - | Once Municipal | 3:4 | ||||
| 8. Jornada | 11.09.2021 | Jocoro FC | - | AD Chalatenango | 3:1 | ||||
| 9. Jornada | 15.09.2021 | Jocoro FC | - | Municipal Limeño | 3:1 |  |
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| 10. Jornada | 19.09.2021 | Platense Zacatecoluca | - | Jocoro FC | 1:1 | ||||
| 11. Jornada | 25.09.2021 | Jocoro FC | - | Alianza | 3:3 | ||||
| 12. Jornada | 02.10.2021 | Jocoro FC | - | Luis Ángel Firpo | 2:1 | ||||
| 13. Jornada | 17.10.2021 | Once Municipal | - | Jocoro FC | 2:2 | ||||
| 14. Jornada | 20.10.2021 | Jocoro FC | - | FAS | 0:0 | ||||
| 15. Jornada | 24.10.2021 | Isidro Metapán | - | Jocoro FC | 1:1 | ||||
| 16. Jornada | 30.10.2021 | Jocoro FC | - | Atlético Marte | 1:1 | ||||
| 17. Jornada | 03.11.2021 | Santa Tecla FC | - | Jocoro FC | 2:1 | |
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| 18. Jornada | 06.11.2021 | Jocoro FC | - | CD Águila | 2:2 | |
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| 19. Jornada | 14.11.2021 | AD Chalatenango | - | Jocoro FC | 2:0 | ||||
| 20. Jornada | 17.11.2021 | Municipal Limeño | - | Jocoro FC | 0:0 |
El Salvador