| 5. Jornada | 21.08.2021 | Santos Laguna [Sub 16] | - | Atlético San Luis [Sub 16] | 2:0 | ||||
| 8. Jornada | 11.09.2021 | Santos Laguna [Sub 16] | - | Mazatlán FC [Sub 16] | 4:2 | ||||
| 15. Jornada | 30.10.2021 | Santos Laguna [Sub 16] | - | Club Necaxa [Sub 16] | 2:1 | ||||
| 16. Jornada | 06.11.2021 | UANL Tigres [Sub 16] | - | Santos Laguna [Sub 16] | 4:0 | ||||
| 17. Jornada | 13.11.2021 | Santos Laguna [Sub 16] | - | Deportivo Guadalajara [Sub 16] | 0:1 |
México