| 1. Jornada | 17.03.2021 | Atlético Porteño | - | Atlético Santo Domingo | 1:1 |  |
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| 3. Jornada | 01.04.2021 | Cumbayá | - | Atlético Santo Domingo | 2:1 | ||||
| 4. Jornada | 06.04.2021 | Atlético Santo Domingo | - | Independiente Juniors | 1:1 |  |
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| 5. Jornada | 14.04.2021 | Chacaritas FC | - | Atlético Santo Domingo | 1:0 | ||||
| 6. Jornada | 21.04.2021 | Atlético Santo Domingo | - | Gualaceo SC | 1:0 | |
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| 7. Jornada | 05.05.2021 | Guayaquil SC | - | Atlético Santo Domingo | 0:1 | ||||
| 8. Jornada | 13.05.2021 | El Nacional | - | Atlético Santo Domingo | 1:0 | ||||
| 9. Jornada | 20.05.2021 | Atlético Santo Domingo | - | Liga de Portoviejo | 3:2 | ||||
| 14. Jornada | 13.06.2021 | Gualaceo SC | - | Atlético Santo Domingo | 3:0 | ||||
| 15. Jornada | 16.06.2021 | Atlético Santo Domingo | - | Guayaquil SC | 0:1 | ||||
| 16. Jornada | 20.06.2021 | Atlético Santo Domingo | - | El Nacional | 0:2 | ||||
| 17. Jornada | 23.06.2021 | Liga de Portoviejo | - | Atlético Santo Domingo | 2:0 | ||||
| 18. Jornada | 27.06.2021 | Atlético Santo Domingo | - | Atlético Porteño | 2:1 | ||||
| 19. Jornada | 03.07.2021 | Atlético Santo Domingo | - | Gualaceo SC | 1:4 | ||||
| 20. Jornada | 08.07.2021 | Chacaritas FC | - | Atlético Santo Domingo | 2:1 | |
Ecuador