| 1. Jornada | 18.01.2021 | Defensor Sporting | - | Montevideo Wanderers | 1:1 | ||||
| 2. Jornada | 28.01.2021 | Peñarol | - | Defensor Sporting | 1:2 | ||||
| 3. Jornada | 01.02.2021 | Defensor Sporting | - | River Plate | 0:2 | ||||
| 4. Jornada | 04.02.2021 | Montevideo City Torque | - | Defensor Sporting | 0:0 | ||||
| 5. Jornada | 07.02.2021 | Defensor Sporting | - | Plaza Colonia | 3:2 | ||||
| 6. Jornada | 11.02.2021 | Progreso | - | Defensor Sporting | 3:3 | ||||
| 7. Jornada | 15.02.2021 | Defensor Sporting | - | Fénix | 2:2 | ||||
| 8. Jornada | 18.02.2021 | CA Cerro | - | Defensor Sporting | 0:0 |  |
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| 9. Jornada | 20.02.2021 | Defensor Sporting | - | Liverpool | 0:3 | |
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| 10. Jornada | 28.02.2021 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 12. Jornada | 12.03.2021 | Defensor Sporting | - | Boston River | 1:2 | ||||
| 13. Jornada | 18.03.2021 | Deportivo Maldonado | - | Defensor Sporting | 2:1 | ||||
| 14. Jornada | 25.03.2021 | Defensor Sporting | - | Rentistas | 0:0 | ||||
| 15. Jornada | 29.03.2021 | Cerro Largo | - | Defensor Sporting | 0:0 |
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