| 1. Jornada | 01.08.2021 | Once Municipal | - | CD Águila | 2:2 | ||||
| 3. Jornada | 11.08.2021 | Once Municipal | - | Municipal Limeño | 4:1 | ||||
| 6. Jornada | 25.08.2021 | Luis Ángel Firpo | - | Once Municipal | 2:2 | ||||
| 7. Jornada | 29.08.2021 | AD Chalatenango | - | Once Municipal | 1:2 | ||||
| 5. Jornada | 10.09.2021 | Alianza | - | Once Municipal | 1:0 |  |
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| 12. Jornada | 03.10.2021 | CD Águila | - | Once Municipal | 1:2 | ||||
| 13. Jornada | 17.10.2021 | Once Municipal | - | Jocoro FC | 2:2 | ||||
| 15. Jornada | 24.10.2021 | Once Municipal | - | Platense Zacatecoluca | 1:1 | ||||
| 16. Jornada | 30.10.2021 | Once Municipal | - | Alianza | 2:3 | ||||
| 17. Jornada | 02.11.2021 | Once Municipal | - | Luis Ángel Firpo | 1:0 | ||||
| 18. Jornada | 07.11.2021 | Once Municipal | - | AD Chalatenango | 1:2 |  |
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| 19. Jornada | 14.11.2021 | FAS | - | Once Municipal | 3:2 | ||||
| 20. Jornada | 18.11.2021 | Once Municipal | - | Isidro Metapán | 1:1 | ||||
| 22. Jornada | 27.11.2021 | Once Municipal | - | Santa Tecla FC | 4:3 |
El Salvador