| 6. Jornada | 13.08.2021 | Mannucci | - | Deportivo Binacional | 3:1 | ||||
| 7. Jornada | 17.08.2021 | Cusco FC | - | Mannucci | 2:3 | ||||
| 9. Jornada | 28.08.2021 | Alianza Atlético | - | Mannucci | 2:0 | ||||
| 10. Jornada | 12.09.2021 | Mannucci | - | Universidad Técnica | 1:3 | ||||
| 11. Jornada | 18.09.2021 | Mannucci | - | Alianza Universidad | 1:1 | ||||
| 12. Jornada | 22.09.2021 | Sporting Cristal | - | Mannucci | 1:3 |  |
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| 13. Jornada | 25.09.2021 | Mannucci | - | Cienciano | 1:3 | ||||
| 14. Jornada | 01.10.2021 | Ayacucho FC | - | Mannucci | 3:2 | ||||
| 15. Jornada | 16.10.2021 | Mannucci | - | Alianza Lima | 0:1 | |
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| 16. Jornada | 22.10.2021 | Sport Boys | - | Mannucci | 3:3 | |
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