| 1. Jornada | 01.08.2021 | Real Estelí FC | - | H&H Export Sébaco | 4:0 | ||||
| 4. Jornada | 22.08.2021 | H&H Export Sébaco | - | Managua FC | 0:0 | ||||
| 8. Jornada | 19.09.2021 | Diriangén FC | - | H&H Export Sébaco | 1:0 | ||||
| 9. Jornada | 26.09.2021 | Real Madriz | - | H&H Export Sébaco | 3:3 | ||||
| 10. Jornada | 02.10.2021 | H&H Export Sébaco | - | Real Estelí FC | 1:3 | ||||
| 11. Jornada | 10.10.2021 | H&H Export Sébaco | - | UNAN Managua | 1:1 | ||||
| 18. Jornada | 20.11.2021 | H&H Export Sébaco | - | Real Madriz | 2:3 |
Nicaragua