| 13. Jornada | 05.08.2021 | Oriente Petrolero | - | Club San José | 4:0 | ||||
| 14. Jornada | 07.08.2021 | Club San José | - | The Strongest | 0:1 | ||||
| 15. Jornada | 15.08.2021 | Jorge Wilstermann | - | Club San José | 4:0 | ||||
| 16. Jornada | 19.08.2021 | Atlético Palmaflor | - | Club San José | 1:0 | ||||
| 17. Jornada | 21.08.2021 | Club San José | - | Always Ready | 0:4 | ||||
| 18. Jornada | 11.09.2021 | Royal Pari | - | Club San José | 6:1 | ||||
| 19. Jornada | 17.09.2021 | Club San José | - | Real Potosí | 0:0 | ||||
| 20. Jornada | 21.09.2021 | CD Guabirá | - | Club San José | 4:0 | ||||
| 21. Jornada | 25.09.2021 | Club San José | - | Blooming | 1:2 | ||||
| 22. Jornada | 20.10.2021 | Bolívar | - | Club San José | 4:1 | ||||
| 23. Jornada | 22.10.2021 | Club San José | - | Club Aurora | 1:4 | ||||
| 24. Jornada | 28.10.2021 | Real Tomayapo | - | Club San José | 1:0 | ||||
| 25. Jornada | 01.11.2021 | Independiente Petrolero | - | Club San José | 4:0 |  |
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| 29. Jornada | 05.12.2021 | The Strongest | - | Club San José | 2:0 |
Bolivia