| 2. Jornada | 28.01.2021 | Chinandega | - | Real Estelí FC | 2:4 |  |
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| 3. Jornada | 01.02.2021 | Real Madriz | - | Real Estelí FC | 0:1 | |
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| 4. Jornada | 05.02.2021 | Juventus Managua | - | Real Estelí FC | 0:1 | ||||
| 5. Jornada | 08.02.2021 | ART Municipal Jalapa | - | Real Estelí FC | 2:1 | |
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| 6. Jornada | 11.02.2021 | CD Walter Ferretti | - | Real Estelí FC | 0:1 | ||||
| 8. Jornada | 18.02.2021 | Real Estelí FC | - | Junior Managua | 7:0 | |
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| 16. Jornada | 29.04.2021 | Real Estelí FC | - | Diriangén FC | 3:0 | |
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| 17. Jornada | 02.05.2021 | Junior Managua | - | Real Estelí FC | 0:2 | |
Nicaragua