| 1. Jornada | 29.07.2021 | CS Herediano | - | Guadalupe | 0:1 | ||||
| 2. Jornada | 01.08.2021 | Jicaral | - | CS Herediano | 3:2 | ||||
| 3. Jornada | 09.08.2021 | Deportivo Saprissa | - | CS Herediano | 2:3 |  |
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| 4. Jornada | 12.08.2021 | CS Herediano | - | Municipal Pérez Zeledón | 1:0 | ||||
| 5. Jornada | 15.08.2021 | LD Alajuelense | - | CS Herediano | 4:1 | ||||
| 6. Jornada | 18.08.2021 | CS Herediano | - | AD San Carlos | 2:0 | |
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| 7. Jornada | 26.08.2021 | Santos de Guápiles | - | CS Herediano | 2:1 | |
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| 8. Jornada | 29.08.2021 | CS Herediano | - | CS Cartaginés | 2:0 | ||||
| 9. Jornada | 09.09.2021 | AD Guanacasteca | - | CS Herediano | 2:1 | |
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| 10. Jornada | 12.09.2021 | Municipal Grecia | - | CS Herediano | 1:2 | ||||
| 11. Jornada | 17.09.2021 | CS Herediano | - | Sporting FC | 3:0 | |
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| 13. Jornada | 26.09.2021 | CS Herediano | - | Jicaral | 1:0 | ||||
| 14. Jornada | 04.10.2021 | CS Herediano | - | Deportivo Saprissa | 2:1 | ||||
| 19. Jornada | 31.10.2021 | CS Cartaginés | - | CS Herediano | 0:1 | ||||
| 20. Jornada | 22.11.2021 | CS Herediano | - | AD Guanacasteca | 5:0 |
Costa Rica