| 2. Jornada | 20.03.2021 | FK Minsk | - | Rukh Brest | 2:2 |  |
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| 5. Jornada | 18.04.2021 | Rukh Brest | - | FK Smorgon | 5:0 | ||||
| 6. Jornada | 25.04.2021 | Shakhter Soligorsk | - | Rukh Brest | 4:1 | ||||
| 7. Jornada | 30.04.2021 | Rukh Brest | - | FK Slaviya Mozyr | 2:1 | ||||
| 8. Jornada | 08.05.2021 | Rukh Brest | - | Sputnik Rechytsa | 2:0 | ||||
| 9. Jornada | 15.05.2021 | BATE Borisov | - | Rukh Brest | 3:2 | ||||
| 12. Jornada | 13.06.2021 | Rukh Brest | - | Torpedo-BelAZ Zhodino | 3:0 | ||||
| 13. Jornada | 19.06.2021 | FK Vitebsk | - | Rukh Brest | 0:0 | ||||
| 14. Jornada | 27.06.2021 | Rukh Brest | - | FK Slutsk | 1:0 | ||||
| 16. Jornada | 17.07.2021 | FK Gomel | - | Rukh Brest | 0:0 | ||||
| 17. Jornada | 23.07.2021 | Rukh Brest | - | FK Minsk | 1:0 | ||||
| 18. Jornada | 30.07.2021 | Energetik-BGU Minsk | - | Rukh Brest | 0:2 | ||||
| 27. Jornada | 24.10.2021 | Torpedo-BelAZ Zhodino | - | Rukh Brest | 3:3 | ||||
| 28. Jornada | 05.11.2021 | Rukh Brest | - | FK Vitebsk | 2:0 |
Bielorrusia