| 3. Jornada | 22.09.2021 | Olympiacos | - | Apollon Smyrnis | 4:1 | ||||
| 4. Jornada | 27.09.2021 | Apollon Smyrnis | - | Ionikos Nikea | 0:0 | ||||
| 5. Jornada | 02.10.2021 | Aris Saloniki | - | Apollon Smyrnis | 0:0 | ||||
| 6. Jornada | 16.10.2021 | Apollon Smyrnis | - | Asteras Tripolis | 0:1 | ||||
| 7. Jornada | 23.10.2021 | Apollon Smyrnis | - | PAS Giannina | 1:0 | ||||
| 8. Jornada | 30.10.2021 | PAOK Saloniki | - | Apollon Smyrnis | 4:1 | ||||
| 9. Jornada | 06.11.2021 | Apollon Smyrnis | - | AEK Athen | 2:2 | ||||
| 10. Jornada | 21.11.2021 | Panetolikos | - | Apollon Smyrnis | 1:0 | ||||
| 11. Jornada | 27.11.2021 | Apollon Smyrnis | - | Lamia | 0:0 | ||||
| 12. Jornada | 04.12.2021 | Atromitos | - | Apollon Smyrnis | 4:1 | ||||
| 19. Jornada | 24.01.2022 | Asteras Tripolis | - | Apollon Smyrnis | 1:0 | ||||
| 24. Jornada | 20.02.2022 | Lamia | - | Apollon Smyrnis | 1:2 | ||||
| 17. Jornada | 23.02.2022 | Ionikos Nikea | - | Apollon Smyrnis | 4:0 | ||||
| 25. Jornada | 28.02.2022 | Apollon Smyrnis | - | Atromitos | 0:2 | ||||
| 26. Jornada | 06.03.2022 | OFI Heraklion | - | Apollon Smyrnis | 2:0 |
Grecia