| 1. Jornada | 05.03.2022 | Spartak Trnava | - | ŠKF Sereď | 0:1 |  |
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| 2. Jornada | 13.03.2022 | FC DAC 1904 | - | Spartak Trnava | 1:1 | |
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| 3. Jornada | 20.03.2022 | MFK Ružomberok | - | Spartak Trnava | 0:0 | ||||
| 4. Jornada | 03.04.2022 | Spartak Trnava | - | Slovan Bratislava | 0:1 | ||||
| 5. Jornada | 09.04.2022 | Spartak Trnava | - | MŠK Žilina | 1:0 | ||||
| 6. Jornada | 17.04.2022 | ŠKF Sereď | - | Spartak Trnava | 0:2 | ||||
| 7. Jornada | 24.04.2022 | Spartak Trnava | - | MFK Ružomberok | 0:0 | ||||
| 8. Jornada | 01.05.2022 | Slovan Bratislava | - | Spartak Trnava | 1:0 | ||||
| 9. Jornada | 14.05.2022 | MŠK Žilina | - | Spartak Trnava | 1:2 | ||||
| 10. Jornada | 21.05.2022 | Spartak Trnava | - | FC DAC 1904 | 1:0 |
Eslovaquia