| 1. Jornada | 14.08.2021 | Mosta FC | - | Birkirkara FC | 0:3 | ||||
| 2. Jornada | 21.08.2021 | Birkirkara FC | - | Hamrun Spartans | 2:1 | ||||
| 3. Jornada | 12.09.2021 | Balzan FC | - | Birkirkara FC | 1:2 | ||||
| 4. Jornada | 19.09.2021 | Birkirkara FC | - | Floriana FC | 1:1 | ||||
| 5. Jornada | 26.09.2021 | Gżira United | - | Birkirkara FC | 1:1 |  |
|||
| 6. Jornada | 16.10.2021 | Birkirkara FC | - | Gudja United | 2:0 | |
|||
| 7. Jornada | 24.10.2021 | Sirens FC | - | Birkirkara FC | 3:2 | ||||
| 8. Jornada | 30.10.2021 | Birkirkara FC | - | Hibernians FC | 1:1 | |
|||
| 14. Jornada | 19.01.2022 | Birkirkara FC | - | Balzan FC | 3:2 | ||||
| 17. Jornada | 06.02.2022 | Gudja United | - | Birkirkara FC | 0:1 | ||||
| 18. Jornada | 13.02.2022 | Birkirkara FC | - | Sirens FC | 1:1 | |
|||
| 20. Jornada | 27.02.2022 | Birkirkara FC | - | St. Luċija FC | 2:3 | ||||
| 21. Jornada | 06.03.2022 | Sliema Wanderers | - | Birkirkara FC | 0:0 | ||||
| 22. Jornada | 12.03.2022 | Birkirkara FC | - | Valletta FC | 1:1 |
Malta