| 6. Jornada | 12.09.2020 | Slovan Bratislava | - | Spartak Trnava | 2:0 |  |
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| 7. Jornada | 19.09.2020 | Spartak Trnava | - | Zlaté Moravce | 1:0 | ||||
| 8. Jornada | 26.09.2020 | FK Senica | - | Spartak Trnava | 0:2 | |
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| 9. Jornada | 03.10.2020 | Spartak Trnava | - | FC Nitra | 0:2 | ||||
| 10. Jornada | 18.10.2020 | MŠK Žilina | - | Spartak Trnava | 2:1 | ||||
| 11. Jornada | 24.10.2020 | Spartak Trnava | - | AS Trenčín | 2:0 | ||||
| 12. Jornada | 31.10.2020 | Spartak Trnava | - | MFK Zemplín Michalovce | 1:2 | |
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| 13. Jornada | 07.11.2020 | MFK Ružomberok | - | Spartak Trnava | 0:1 | ||||
| 14. Jornada | 21.11.2020 | FK Pohronie | - | Spartak Trnava | 3:3 |  |
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| 15. Jornada | 28.11.2020 | Spartak Trnava | - | FC DAC 1904 | 0:2 | |
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| 16. Jornada | 05.12.2020 | ŠKF Sereď | - | Spartak Trnava | 2:6 | ||||
| 17. Jornada | 13.12.2020 | Spartak Trnava | - | Slovan Bratislava | 0:3 | |
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| 19. Jornada | 13.02.2021 | Spartak Trnava | - | FK Senica | 1:0 | ||||
| 20. Jornada | 20.02.2021 | FC Nitra | - | Spartak Trnava | 0:1 | |
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| 21. Jornada | 27.02.2021 | Spartak Trnava | - | MŠK Žilina | 2:1 | ||||
| 22. Jornada | 06.03.2021 | AS Trenčín | - | Spartak Trnava | 2:0 |
Grecia