| 1. Jornada | 06.08.2021 | SBV Excelsior | - | TOP Oss | 0:1 | ||||
| 2. Jornada | 13.08.2021 | TOP Oss | - | VVV-Venlo | 2:1 | ||||
| 3. Jornada | 23.08.2021 | AZ Alkmaar (J) | - | TOP Oss | 1:0 | ||||
| 4. Jornada | 28.08.2021 | TOP Oss | - | FC Dordrecht | 3:0 | ||||
| 5. Jornada | 04.09.2021 | Almere City FC | - | TOP Oss | 3:0 | ||||
| 6. Jornada | 10.09.2021 | TOP Oss | - | ADO Den Haag | 3:3 | ||||
| 7. Jornada | 17.09.2021 | Roda JC Kerkrade | - | TOP Oss | 2:0 |  |
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| 10. Jornada | 09.10.2021 | FC Eindhoven | - | TOP Oss | 2:1 | ||||
| 17. Jornada | 26.11.2021 | TOP Oss | - | Telstar | 1:1 | ||||
| 26. Jornada | 11.02.2022 | TOP Oss | - | FC Eindhoven | 1:2 | ||||
| 28. Jornada | 25.02.2022 | TOP Oss | - | FC Utrecht (J) | 4:1 | ||||
| 27. Jornada | 14.03.2022 | FC Dordrecht | - | TOP Oss | 1:0 | ||||
| 33. Jornada | 01.04.2022 | FC Volendam | - | TOP Oss | 1:2 | ||||
| 32. Jornada | 04.04.2022 | Jong Ajax | - | TOP Oss | 4:1 | ||||
| 34. Jornada | 08.04.2022 | TOP Oss | - | Jong PSV | 2:0 |  |
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| 35. Jornada | 15.04.2022 | De Graafschap | - | TOP Oss | 1:2 | ||||
| 36. Jornada | 22.04.2022 | TOP Oss | - | Almere City FC | 2:3 | ||||
| 37. Jornada | 29.04.2022 | NAC Breda | - | TOP Oss | 3:0 | |
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| 38. Jornada | 06.05.2022 | TOP Oss | - | MVV | 0:1 |
Países Bajos
Surinam