| 1. Jornada | 09.02.2022 | Cerrito | - | Danubio | 0:1 | ||||
| 2. Jornada | 15.02.2022 | Deportivo Maldonado | - | Danubio | 1:2 | ||||
| 3. Jornada | 20.02.2022 | Danubio | - | Rentistas | 0:1 | ||||
| 4. Jornada | 26.02.2022 | Liverpool | - | Danubio | 0:1 |  |
|||
| 5. Jornada | 05.03.2022 | Danubio | - | Peñarol | 0:1 | |
|||
| 6. Jornada | 22.03.2022 | Montevideo City Torque | - | Danubio | 1:1 | |
|||
| 7. Jornada | 02.04.2022 | Danubio | - | Montevideo Wanderers | 0:0 | ||||
| 8. Jornada | 09.04.2022 | Plaza Colonia | - | Danubio | 1:1 | ||||
| 9. Jornada | 15.04.2022 | Danubio | - | Boston River | 0:0 |  |
|||
| 11. Jornada | 08.05.2022 | Danubio | - | Cerro Largo | 2:0 | ||||
| 12. Jornada | 15.05.2022 | Fénix | - | Danubio | 0:0 | ||||
| 13. Jornada | 22.05.2022 | Danubio | - | Defensor Sporting | 1:2 | ||||
| 14. Jornada | 27.05.2022 | Albion | - | Danubio | 1:2 | ||||
| 15. Jornada | 05.06.2022 | Danubio | - | Nacional | 2:1 |
Uruguay
Italia