| 1. Jornada | 02.08.2021 | ART Municipal Jalapa | - | Club Deportivo Ocotal | 1:1 |  |
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| 2. Jornada | 08.08.2021 | CD Walter Ferretti | - | Club Deportivo Ocotal | 4:0 | |
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| 3. Jornada | 15.08.2021 | H&H Export Sébaco | - | Club Deportivo Ocotal | 0:1 | ||||
| 4. Jornada | 23.08.2021 | Club Deportivo Ocotal | - | Diriangén FC | 1:1 |  |
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| 5. Jornada | 29.08.2021 | Club Deportivo Ocotal | - | Real Madriz | 2:1 | ||||
| 7. Jornada | 13.09.2021 | Juventus Managua | - | Club Deportivo Ocotal | 3:1 | |
Nicaragua