| 19. Jornada | 05.09.2021 | Deportes Iquique | - | Barnechea | 4:2 | ||||
| 20. Jornada | 16.09.2021 | San Luis | - | Deportes Iquique | 1:1 |  |
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| 21. Jornada | 23.09.2021 | Deportes Iquique | - | Deportes Copiapó | 2:1 | ||||
| 22. Jornada | 27.09.2021 | CD Magallanes | - | Deportes Iquique | 2:2 | ||||
| 23. Jornada | 03.10.2021 | Deportes Iquique | - | Santa Cruz | 6:1 | ||||
| 24. Jornada | 08.10.2021 | Universidad de Concepción | - | Deportes Iquique | 3:1 | ||||
| 25. Jornada | 13.10.2021 | Deportes Iquique | - | Cobreloa | 1:0 | ||||
| 26. Jornada | 20.10.2021 | Deportes Iquique | - | Unión San Felipe | 1:0 | ||||
| 27. Jornada | 25.10.2021 | Santiago Morning | - | Deportes Iquique | 1:0 | ||||
| 28. Jornada | 01.11.2021 | Deportes Iquique | - | Rangers | 2:2 | ||||
| 29. Jornada | 06.11.2021 | Deportes Temuco | - | Deportes Iquique | 2:1 | ||||
| 30. Jornada | 13.11.2021 | Deportes Iquique | - | Puerto Montt | 4:2 |
Chile