| 1. Jornada | 21.01.2021 | Alianza Petrolera | - | Deportivo Pereira | 2:2 |  |
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| 3. Jornada | 30.01.2021 | Jaguares de Córdoba | - | Alianza Petrolera | 2:0 | |
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| 4. Jornada | 04.02.2021 | Alianza Petrolera | - | Águilas Doradas | 1:2 | ||||
| 5. Jornada | 06.02.2021 | Atlético Junior | - | Alianza Petrolera | 2:0 | ||||
| 6. Jornada | 13.02.2021 | Alianza Petrolera | - | Once Caldas | 0:0 | |
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| 7. Jornada | 17.02.2021 | Patriotas FC | - | Alianza Petrolera | 3:1 | |
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| 8. Jornada | 23.02.2021 | Deportivo Cali | - | Alianza Petrolera | 1:1 | ||||
| 9. Jornada | 26.02.2021 | Alianza Petrolera | - | Deportes Tolima | 0:5 | ||||
| 10. Jornada | 03.03.2021 | Atlético Nacional | - | Alianza Petrolera | 5:0 | ||||
| 11. Jornada | 10.03.2021 | Alianza Petrolera | - | Millonarios | 0:2 | |
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| 13. Jornada | 23.03.2021 | Alianza Petrolera | - | Atlético Bucaramanga | 1:3 | ||||
| 14. Jornada | 25.03.2021 | La Equidad | - | Alianza Petrolera | 1:1 | ||||
| 15. Jornada | 28.03.2021 | Alianza Petrolera | - | América de Cali | 0:2 | ||||
| 16. Jornada | 02.04.2021 | Boyacá Chicó | - | Alianza Petrolera | 2:0 | |
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| 17. Jornada | 07.04.2021 | Alianza Petrolera | - | Santa Fe | 0:3 | |
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| 18. Jornada | 10.04.2021 | Independiente Medellín | - | Alianza Petrolera | 2:2 |
Colombia