| 2. Jornada | 31.07.2022 | RFC Seraing | - | KV Kortrijk | 0:1 |  |
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| 3. Jornada | 07.08.2022 | RSC Anderlecht | - | RFC Seraing | 3:1 | ||||
| 4. Jornada | 13.08.2022 | RFC Seraing | - | Sporting Charleroi | 0:1 | ||||
| 5. Jornada | 19.08.2022 | KAS Eupen | - | RFC Seraing | 1:3 | ||||
| 6. Jornada | 27.08.2022 | RFC Seraing | - | KRC Genk | 0:4 | ||||
| 7. Jornada | 03.09.2022 | KV Mechelen | - | RFC Seraing | 2:3 | ||||
| 8. Jornada | 10.09.2022 | RFC Seraing | - | Club Brugge KV | 0:2 | ||||
| 9. Jornada | 16.09.2022 | Royal Antwerp FC | - | RFC Seraing | 2:1 | |
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| 10. Jornada | 30.09.2022 | Standard Liège | - | RFC Seraing | 0:2 | ||||
| 11. Jornada | 08.10.2022 | RFC Seraing | - | KV Oostende | 1:1 | ||||
| 12. Jornada | 14.10.2022 | KVC Westerlo | - | RFC Seraing | 2:2 | ||||
| 13. Jornada | 18.10.2022 | RFC Seraing | - | Cercle Brugge | 0:1 | ||||
| 14. Jornada | 23.10.2022 | Gante | - | RFC Seraing | 2:1 | ||||
| 15. Jornada | 30.10.2022 | RFC Seraing | - | Union Saint-Gilloise | 1:2 | ||||
| 16. Jornada | 05.11.2022 | RFC Seraing | - | Sint-Truidense VV | 1:2 | ||||
| 17. Jornada | 11.11.2022 | Oud-Heverlee Leuven | - | RFC Seraing | 5:0 | ||||
| 18. Jornada | 23.12.2022 | RFC Seraing | - | KAS Eupen | 0:1 |
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