| 1. Jornada | 16.01.2022 | Once Municipal | - | FAS | 1:1 | ||||
| 2. Jornada | 23.01.2022 | Santa Tecla FC | - | Once Municipal | 1:1 | ||||
| 3. Jornada | 26.01.2022 | Once Municipal | - | Municipal Limeño | 3:2 | ||||
| 6. Jornada | 10.02.2022 | AD Chalatenango | - | Once Municipal | 1:0 | ||||
| 9. Jornada | 23.02.2022 | Once Municipal | - | Alianza | 1:2 | ||||
| 11. Jornada | 05.03.2022 | Jocoro FC | - | Once Municipal | 2:1 | ||||
| 14. Jornada | 25.03.2022 | Municipal Limeño | - | Once Municipal | 0:0 | ||||
| 15. Jornada | 03.04.2022 | Once Municipal | - | Atlético Marte | 1:0 | ||||
| 19. Jornada | 24.04.2022 | Once Municipal | - | Platense Zacatecoluca | 1:2 | ||||
| 20. Jornada | 29.04.2022 | Alianza | - | Once Municipal | 1:0 | ||||
| 22. Jornada | 07.05.2022 | Once Municipal | - | Jocoro FC | 0:1 |  |
El Salvador