| 1. Jornada | 25.07.2021 | Tigres FC | - | Bogotá FC | 0:0 | ||||
| 2. Jornada | 30.07.2021 | Atlético FC | - | Tigres FC | 2:1 | ||||
| 3. Jornada | 07.08.2021 | Tigres FC | - | Orsomarso SC | 1:2 |  |
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| 4. Jornada | 15.08.2021 | Valledupar FC | - | Tigres FC | 0:0 | ||||
| 5. Jornada | 23.08.2021 | Tigres FC | - | Boyacá Chicó | 0:1 |  |
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| 6. Jornada | 28.08.2021 | Fortaleza FC | - | Tigres FC | 2:1 | ||||
| 7. Jornada | 06.09.2021 | Tigres FC | - | Real Santander | 2:0 |  |
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| 9. Jornada | 22.09.2021 | Tigres FC | - | Unión Magdalena | 0:0 | ||||
| 10. Jornada | 28.09.2021 | Boca Juniors de Cali | - | Tigres FC | 1:0 | |
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| 11. Jornada | 06.10.2021 | Tigres FC | - | Real Cartagena | 1:2 | ||||
| 15. Jornada | 30.10.2021 | Barranquilla FC | - | Tigres FC | 2:0 |
Colombia