| 3. Jornada | 22.07.2022 | Atlético Huila | - | Real Cartagena | 2:3 |  |
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| 4. Jornada | 29.07.2022 | Real Cartagena | - | Cúcuta Deportivo | 1:2 | ||||
| 5. Jornada | 04.08.2022 | Real Cartagena | - | Orsomarso SC | 0:1 | ||||
| 6. Jornada | 07.08.2022 | Fortaleza FC | - | Real Cartagena | 3:1 | |
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| 7. Jornada | 17.08.2022 | Real Cartagena | - | Real Santander | 2:2 | |
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| 8. Jornada | 24.08.2022 | Boyacá Chicó | - | Real Cartagena | 4:0 | ||||
| 9. Jornada | 31.08.2022 | Real Cartagena | - | Barranquilla FC | 2:2 | |
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| 10. Jornada | 03.09.2022 | Valledupar FC | - | Real Cartagena | 1:1 | |
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| 11. Jornada | 07.09.2022 | Real Cartagena | - | Tigres FC | 0:1 | ||||
| 1. Jornada | 15.09.2022 | Atlético FC | - | Real Cartagena | 0:2 | ||||
| 13. Jornada | 20.09.2022 | Real Cartagena | - | Deportes Quindío | 3:1 | |
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| 14. Jornada | 25.09.2022 | Barranquilla FC | - | Real Cartagena | 2:3 | |
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| 15. Jornada | 01.10.2022 | Real Cartagena | - | Boca Juniors de Cali | 0:0 | ||||
| 16. Jornada | 08.10.2022 | Bogotá FC | - | Real Cartagena | 2:0 |
Colombia