| 1. Jornada | 26.04.2021 | Liaoning Shenyang Urban FC | - | Guizhou FC | 0:1 |  |
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| 2. Jornada | 01.05.2021 | Guizhou FC | - | Suzhou Dongwu | 1:0 | |
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| 3. Jornada | 06.05.2021 | Wuhan Three Towns | - | Guizhou FC | 0:1 | |
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| 4. Jornada | 11.05.2021 | Guizhou FC | - | Heilongjiang Ice City | 0:1 | ||||
| 23. Jornada | 21.09.2021 | Guizhou FC | - | Nantong Zhiyun | 0:2 | ||||
| 24. Jornada | 26.09.2021 | Xinjiang Tianshan Leopard | - | Guizhou FC | 1:1 | |
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| 26. Jornada | 04.10.2021 | Beijing BSU | - | Guizhou FC | 1:1 | ||||
| 27. Jornada | 22.11.2021 | Meizhou Hakka | - | Guizhou FC | 4:2 | ||||
| 28. Jornada | 25.11.2021 | Guizhou FC | - | Zhejiang Professional | 0:0 | |
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| 29. Jornada | 29.11.2021 | Guizhou FC | - | Kunshan FC | 0:4 | ||||
| 30. Jornada | 05.12.2021 | Chengdu Rongcheng | - | Guizhou FC | 5:0 |  |
China