| 1. Jornada | 16.01.2011 | Club Aurora | - | Club San José | 1:1 | ||||
| 2. Jornada | 23.01.2011 | Club San José | - | Universitario de Sucre | 2:1 | ||||
| 3. Jornada | 30.01.2011 | Nacional Potosí | - | Club San José | 3:0 | ||||
| 4. Jornada | 06.02.2011 | Club San José | - | Bolívar | 3:2 |  |
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| 5. Jornada | 13.02.2011 | Oriente Petrolero | - | Club San José | 2:1 | |
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| 7. Jornada | 24.02.2011 | La Paz FC | - | Club San José | 1:0 | ||||
| 8. Jornada | 26.02.2011 | Club San José | - | Real Potosí | 2:1 |  |
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| 10. Jornada | 20.03.2011 | Club San José | - | Blooming | 2:1 | |
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| 11. Jornada | 03.04.2011 | CD Guabirá | - | Club San José | 3:1 | ||||
| 13. Jornada | 17.04.2011 | Universitario de Sucre | - | Club San José | 0:1 | ||||
| 15. Jornada | 24.04.2011 | Bolívar | - | Club San José | 3:2 | ||||
| 16. Jornada | 01.05.2011 | Club San José | - | Oriente Petrolero | 1:0 | |
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| 17. Jornada | 08.05.2011 | Real Mamoré | - | Club San José | 2:0 | |
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| 19. Jornada | 15.05.2011 | Real Potosí | - | Club San José | 1:1 | ||||
| 20. Jornada | 19.05.2011 | Club San José | - | The Strongest | 2:1 | |
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| 21. Jornada | 22.05.2011 | Blooming | - | Club San José | 2:1 | ||||
| 22. Jornada | 29.05.2011 | Club San José | - | CD Guabirá | 5:0 |
Bolivia