| 1. Jornada | 14.08.2021 | RWD Molenbeek | - | Royal Excel Mouscron | 3:1 |  |
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| 3. Jornada | 29.08.2021 | Royal Excel Mouscron | - | Waasland-Beveren | 0:4 | ||||
| 4. Jornada | 10.09.2021 | KMSK Deinze | - | Royal Excel Mouscron | 3:1 | ||||
| 5. Jornada | 18.09.2021 | Royal Excel Mouscron | - | Excelsior Virton | 1:1 |  |
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| 6. Jornada | 26.09.2021 | Royal Excel Mouscron | - | KVC Westerlo | 1:2 | ||||
| 7. Jornada | 02.10.2021 | Lierse Kempenzonen | - | Royal Excel Mouscron | 2:2 | ||||
| 8. Jornada | 17.10.2021 | Lommel SK | - | Royal Excel Mouscron | 3:0 | ||||
| 9. Jornada | 22.10.2021 | Royal Excel Mouscron | - | RWD Molenbeek | 1:1 | |
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| 10. Jornada | 29.10.2021 | Excelsior Virton | - | Royal Excel Mouscron | 0:2 | ||||
| 11. Jornada | 06.11.2021 | Royal Excel Mouscron | - | KMSK Deinze | 2:0 | |
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| 12. Jornada | 19.11.2021 | Waasland-Beveren | - | Royal Excel Mouscron | 0:2 | ||||
| 13. Jornada | 28.11.2021 | Royal Excel Mouscron | - | Lierse Kempenzonen | 2:1 | |
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| 14. Jornada | 05.12.2021 | KVC Westerlo | - | Royal Excel Mouscron | 4:3 | ||||
| 15. Jornada | 11.12.2021 | Royal Excel Mouscron | - | Lommel SK | 2:1 | ||||
| 16. Jornada | 18.12.2021 | KMSK Deinze | - | Royal Excel Mouscron | 2:2 | |
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