| 1. Jornada | 18.01.2021 | Defensor Sporting | - | Montevideo Wanderers | 1:1 | ||||
| 2. Jornada | 28.01.2021 | Peñarol | - | Defensor Sporting | 1:2 |  |
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| 3. Jornada | 01.02.2021 | Defensor Sporting | - | River Plate | 0:2 | |
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| 4. Jornada | 04.02.2021 | Montevideo City Torque | - | Defensor Sporting | 0:0 | |
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| 8. Jornada | 18.02.2021 | CA Cerro | - | Defensor Sporting | 0:0 | ||||
| 15. Jornada | 29.03.2021 | Cerro Largo | - | Defensor Sporting | 0:0 | |
Uruguay