| 1. Jornada | 25.06.2022 | Santos Laguna [] | - | Deportivo Guadalajara [] | 0:1 | ||||
| 2. Jornada | 02.07.2022 | Club Tijuana [] | - | Santos Laguna [] | 2:0 | ||||
| 3. Jornada | 09.07.2022 | Santos Laguna [] | - | CF Monterrey [] | 3:5 | ||||
| 4. Jornada | 16.07.2022 | Atlético San Luis [] | - | Santos Laguna [] | 2:7 |  |
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| 5. Jornada | 23.07.2022 | Santos Laguna [] | - | Mazatlán FC [] | 5:0 | ||||
| 8. Jornada | 13.08.2022 | Santos Laguna [] | - | UANL Tigres [] | 2:2 | ||||
| 11. Jornada | 03.09.2022 | Santos Laguna [] | - | Club León [] | 2:0 | ||||
| 16. Jornada | 08.10.2022 | Santos Laguna [] | - | Atlético San Luis [] | 4:0 | ||||
| 18. Jornada | 22.10.2022 | Santos Laguna [] | - | Club Tijuana [] | 1:0 |
México